Lymphadenectomy for the management of endometrial cancer.
Identifieur interne : 001B83 ( Main/Exploration ); précédent : 001B82; suivant : 001B84Lymphadenectomy for the management of endometrial cancer.
Auteurs : Jonathan A. Frost ; Katie E. Webster ; Andrew Bryant ; Jo MorrisonSource :
- The Cochrane database of systematic reviews [ 1469-493X ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Lymphadénectomie.
- étiologie : Lymphocèle, Lymphoedème.
- Adulte, Essais contrôlés randomisés comme sujet, Femelle, Humains, Métastase lymphatique, Qualité de vie, Survie sans rechute, Tumeurs de l'endomètre.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Lymph Node Excision.
- etiology : Lymphedema, Lymphocele.
- surgery : Endometrial Neoplasms.
- Adult, Disease-Free Survival, Female, Humans, Lymphatic Metastasis, Quality of Life, Randomized Controlled Trials as Topic.
Abstract
This is an update of a previous Cochrane review published in Issue 1, 2010. The role of lymphadenectomy in surgical management of endometrial cancer remains controversial. Lymph node metastases can be found in approximately 10% of women who clinically before surgery have cancer confined to the womb. Removal of all pelvic and para-aortic lymph nodes (lymphadenectomy) at initial surgery has been widely advocated, and pelvic and para-aortic lymphadenectomy remains part of the FIGO (International Federation of Gynaecology and Obstetrics) staging system for endometrial cancer. This recommendation is based on data from studies that suggested improvement in survival following pelvic and para-aortic lymphadenectomy. However, these studies were not randomised controlled trials (RCTs), and treatment of pelvic lymph nodes may not confer a direct therapeutic benefit, other than allocating women to poorer prognosis groups. Furthermore, the Cochrane review and meta-analysis of RCTs of routine adjuvant radiotherapy to treat possible lymph node metastases in women with early-stage endometrial cancer found no survival advantage. Surgical removal of pelvic and para-aortic lymph nodes has serious potential short-term and long-term sequelae. Therefore it is important to investigate the clinical value of this treatment.
DOI: 10.1002/14651858.CD007585.pub3
PubMed: 26387863
Affiliations:
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Le document en format XML
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Webster</name></author><author><name sortKey="Bryant, Andrew" sort="Bryant, Andrew" uniqKey="Bryant A" first="Andrew" last="Bryant">Andrew Bryant</name></author><author><name sortKey="Morrison, Jo" sort="Morrison, Jo" uniqKey="Morrison J" first="Jo" last="Morrison">Jo Morrison</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26387863</idno><idno type="pmid">26387863</idno><idno type="doi">10.1002/14651858.CD007585.pub3</idno><idno type="wicri:Area/PubMed/Corpus">000C41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C41</idno><idno type="wicri:Area/PubMed/Curation">000C41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C41</idno><idno type="wicri:Area/PubMed/Checkpoint">000C41</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C41</idno><idno type="wicri:Area/Ncbi/Merge">007904</idno><idno type="wicri:Area/Ncbi/Curation">007904</idno><idno type="wicri:Area/Ncbi/Checkpoint">007904</idno><idno type="wicri:Area/Main/Merge">001B86</idno><idno type="wicri:Area/Main/Curation">001B83</idno><idno type="wicri:Area/Main/Exploration">001B83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphadenectomy for the management of endometrial cancer.</title><author><name sortKey="Frost, Jonathan A" sort="Frost, Jonathan A" uniqKey="Frost J" first="Jonathan A" last="Frost">Jonathan A. Frost</name><affiliation><nlm:affiliation>Obstetrics and Gynaecology, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, UK, GL1 3NN.</nlm:affiliation><wicri:noCountry code="subField">GL1 3NN</wicri:noCountry></affiliation></author><author><name sortKey="Webster, Katie E" sort="Webster, Katie E" uniqKey="Webster K" first="Katie E" last="Webster">Katie E. Webster</name></author><author><name sortKey="Bryant, Andrew" sort="Bryant, Andrew" uniqKey="Bryant A" first="Andrew" last="Bryant">Andrew Bryant</name></author><author><name sortKey="Morrison, Jo" sort="Morrison, Jo" uniqKey="Morrison J" first="Jo" last="Morrison">Jo Morrison</name></author></analytic><series><title level="j">The Cochrane database of systematic reviews</title><idno type="eISSN">1469-493X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Disease-Free Survival</term><term>Endometrial Neoplasms (surgery)</term><term>Female</term><term>Humans</term><term>Lymph Node Excision (adverse effects)</term><term>Lymphatic Metastasis</term><term>Lymphedema (etiology)</term><term>Lymphocele (etiology)</term><term>Quality of Life</term><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Essais contrôlés randomisés comme sujet</term><term>Femelle</term><term>Humains</term><term>Lymphadénectomie (effets indésirables)</term><term>Lymphocèle (étiologie)</term><term>Lymphoedème (étiologie)</term><term>Métastase lymphatique</term><term>Qualité de vie</term><term>Survie sans rechute</term><term>Tumeurs de l'endomètre ()</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Lymphadénectomie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term><term>Lymphocele</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Endometrial Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphocèle</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Lymphatic Metastasis</term><term>Quality of Life</term><term>Randomized Controlled Trials as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Essais contrôlés randomisés comme sujet</term><term>Femelle</term><term>Humains</term><term>Métastase lymphatique</term><term>Qualité de vie</term><term>Survie sans rechute</term><term>Tumeurs de l'endomètre</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This is an update of a previous Cochrane review published in Issue 1, 2010. The role of lymphadenectomy in surgical management of endometrial cancer remains controversial. Lymph node metastases can be found in approximately 10% of women who clinically before surgery have cancer confined to the womb. Removal of all pelvic and para-aortic lymph nodes (lymphadenectomy) at initial surgery has been widely advocated, and pelvic and para-aortic lymphadenectomy remains part of the FIGO (International Federation of Gynaecology and Obstetrics) staging system for endometrial cancer. This recommendation is based on data from studies that suggested improvement in survival following pelvic and para-aortic lymphadenectomy. However, these studies were not randomised controlled trials (RCTs), and treatment of pelvic lymph nodes may not confer a direct therapeutic benefit, other than allocating women to poorer prognosis groups. Furthermore, the Cochrane review and meta-analysis of RCTs of routine adjuvant radiotherapy to treat possible lymph node metastases in women with early-stage endometrial cancer found no survival advantage. Surgical removal of pelvic and para-aortic lymph nodes has serious potential short-term and long-term sequelae. Therefore it is important to investigate the clinical value of this treatment.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bryant, Andrew" sort="Bryant, Andrew" uniqKey="Bryant A" first="Andrew" last="Bryant">Andrew Bryant</name><name sortKey="Frost, Jonathan A" sort="Frost, Jonathan A" uniqKey="Frost J" first="Jonathan A" last="Frost">Jonathan A. Frost</name><name sortKey="Morrison, Jo" sort="Morrison, Jo" uniqKey="Morrison J" first="Jo" last="Morrison">Jo Morrison</name><name sortKey="Webster, Katie E" sort="Webster, Katie E" uniqKey="Webster K" first="Katie E" last="Webster">Katie E. 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